Clearing the desk

Tachyphylaxis is a medical term describing 'A rapid decrease in the response to a drug after repeated doses over a short period of time'. Increasing the dose of the drug will not increase the pharmacological response. Tachyphylaxis may develop with an initial dose. The cause of this phenomenon is depletion of the neurotransmitter that is involved in the action of the drug. The drug causing tachyphylaxis acts indirectly by causing release of the stored neurotransmitter from the nerve terminal. After a few doses the neurotransmitter stores are depleted and no more response is obtained...http://en.wikipedia.org/wiki/Tachyphylaxis

isocoric pupils - equal

storage diseases; adreno leukodystrophy, metachromatic leukodystrophy, globoid cell LD, LD syndrome, hurler S, Hunter S, Sanfillipo S.